Pyridine C(sp²)–H bond functionalization under transition-metal and rare earth metal catalysis

• Haritha Sindhe,
• Malladi Mounika Reddy,
• Karthikeyan Rajkumar,
• Akshay Kamble,
• Amardeep Singh,
• Anand Kumar and
• Satyasheel Sharma

Beilstein J. Org. Chem. 2023, 19, 820–863, doi:10.3762/bjoc.19.62

• for the first time an enantioselective C-2 alkylation of pyridine using a chiral phosphine oxide-ligated Ni–Al bimetallic catalyst system and the protocol was found effective for a wide range of pyridines including unsubstituted pyridines, C2, C3 and C4-substituted pyridines and complex pyridines

• containing bioactive molecules (Scheme 10). To attain enantioselectivity a chiral phosphine oxide (43)-ligated Ni–Al bimetallic catalyst was used that was critical in improving the reactivity and controlling the selectivity of the reaction. Further, based on deuterium labelling experiments, KIE studies, and

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

• Guido Gambacorta,
• James S. Sharley and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

• ). Packed-bed reactors have also been exploited to facilitate enantioselective nitroaldol processes. In 2013, Shibasaki and Kumagai made use of an entangling network of multiwalled carbon nanotubes (MWNT) to trap a Nd/Na bimetallic catalyst, which was shown to be an efficient combination for nitroaldol

Cu(I)-catalyzed N,N’-diarylation of natural diamines and polyamines with aryl iodides

• Svetlana P. Panchenko,
• Alexei D. Averin,
• Maksim V. Anokhin,
• Olga A. Maloshitskaya and
• Irina P. Beletskaya

Beilstein J. Org. Chem. 2015, 11, 2297–2305, doi:10.3762/bjoc.11.250

• the literature. One of them employs an iridium-based catalyst with amidophosphonate as the ligand which allows to convert aminoalcohols into N-monoaryl-substituted diamines by the reaction with arylamines [20]. Another method uses a bimetallic catalyst (Pt–Sn/γ-Al2O3) in the reactions of diols with

Practical synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides via conventional and decarboxylative copper-free Sonogashira coupling reactions

• Andrea Caporale,
• Stefano Tartaggia,
• Andrea Castellin and
• Ottorino De Lucchi

Beilstein J. Org. Chem. 2014, 10, 384–393, doi:10.3762/bjoc.10.36

• presence of a Cu/Pd bimetallic catalyst, followed by the basic cleavage of the protecting group [42][43][44][45][46]. Terminal alkynes are often used as starting materials for the synthesis of disubstituted acetylenes through a second coupling process with another aryl halide. Decarboxylative couplings

Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst

• Cybille Rossy,
• Eric Fouquet and
• François-Xavier Felpin

Beilstein J. Org. Chem. 2013, 9, 1426–1431, doi:10.3762/bjoc.9.160

• procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups. Keywords: benzofuran; bimetallic catalyst; heterogeneous catalysis; indole; water; Introduction Heterocycles are ubiquitous building blocks in natural products, bioactive compounds and

• concomitant impregnation of charcoal with palladium and copper could lead to a heterogeneous bimetallic catalyst, hopefully active for cascade Sonogashira alkynylation–cyclization sequences. Following this aim, we were pleased to find that the stirring of a mixture of Pd(OAc)2, Cu(OAc)2 and activated charcoal

• in MeOH under an atmosphere of H2 (1 atm) furnished a heterogeneous bimetallic catalyst. The content of Pd (~5 wt %) and Cu (~3.6 wt %) was determined by ICPMS analysis. With the aim of developing a heterogeneous bimetallic catalysis in water, we took inspiration from the work of Pal et al [34], who

Tandem catalysis of ring-closing metathesis/atom transfer radical reactions with homobimetallic ruthenium–arene complexes

• Yannick Borguet,
• Xavier Sauvage,
• Guillermo Zaragoza,
• Albert Demonceau and
• Lionel Delaude

Beilstein J. Org. Chem. 2010, 6, 1167–1173, doi:10.3762/bjoc.6.133

• additional N-protected octadienyl trichloro- or tribromoacetamide substrates and we followed their transformation under the influence of bimetallic catalyst precursor 1 (see Supporting Information File 1 for details). As expected, N-benzyl trichloroacetamide 8 underwent the RCM/ATRC sequence at a lower